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Renal dysplasia in dogs

Renal dysplasia in dogs


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Renal dysplasia in dogs: a study of histological features and risk factors.

To determine whether dogs with renal dysplasia were more likely to have been diagnosed with hereditary renal tumours than were dogs without dysplasia. To determine whether any breed, age, sex, bodyweight or history of nephrectomy were associated with renal dysplasia, or if dogs receiving treatment with angiotensin converting enzyme inhibitors or statins were less likely to have dysplasia. Histopathological and demographic data were retrieved from the canine cancer database of the Small Animal Teaching Hospital at the University of Glasgow. The incidence of renal dysplasia was 3.6 per cent. In univariate analysis, older age at diagnosis was associated with dysplasia, and the following breeds were over-represented in the dysplastic group: the Dobermann Pinscher, the Labrador Retriever, the Cocker Spaniel and the Shih Tzu. Bodyweight was not significantly associated with dysplasia. Dogs that had a history of nephrectomy were no more likely to have dysplasia than dogs that had not been treated with nephrectomy. In multivariable analysis, only the Dobermann Pinscher and Cocker Spaniel were associated with dysplasia. Only 6.8 per cent of dogs with dysplasia received angiotensin converting enzyme inhibitor treatment, compared with 15.4 per cent of dogs with non-dysplastic lesions. These results may be of use to clinicians when assessing the need for a renal biopsy in dogs with suspected dysplasia. A further prospective study is needed to determine whether the presence of a risk factor in dogs with non-dysplastic renal lesions is helpful in making the decision to biopsy.


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